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In patients with early PD, the GLP-1RA lixisenatide can modestly slow the progression of motor dysfunction over 12 months of treatment, but it is associated with gastrointestinal side effects, and its long-term efficacy and safety require further verification (265)

Clinical trials for semaglutide have shown fatigue as a side effect, but its usually temporary

At 52 weeks, semaglutide-treated patients saw a mean improvement of 16.6 points in their scores on the Kansas City Cardiomyopathy Questionnaire (KCCQ), a validated measure of heart failure-related symptoms and physical limitations, compared with an 8.7-point improvement in the placebo group

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Copper contributes to angiogenesis, hemoglobin synthesis, and redox balance and acts as a cofactor for enzymes such as superoxide dismutase 23